Susan Merenstein, Pharmacist/Owner

(412) 586-4678


Menopause is the best time in a women’s life if her hormones are balanced!

Synthetic HRT: Other Problems

  • It is estimated that one-half of women quit taking their synthetic hormone replacement therapy after one year because they are unable to tolerate the side effects.
  • Synthetic hormones waste energy by giving incomplete messages to cells which then fail to produce a balanced hormonal response.

Symptoms of Menopause

  • Hot flashes
  • Night sweats
  • Vaginal dryness
  • Anxiety
  • Mood swings
  • Irritability
  • Insomnia
  • Depression
  • Loss of sexual interest
  • Hair growth on face
  • Painful intercourse
  • Panic attacks
  • Weird dreams
  • Urinary tract infections
  • Vaginal itching
  • Lower back pain
  • Bloating
  • Flatulence
  • Indigestion
  • Osteoporosis
  • Aching ankles, knees, wrists, shoulders, heels
  • Hair loss
  • Frequent urination
  • Snoring
  • Sore breasts
  • Palpitations
  • Varicose veins
  • Urinary leakage
  • Dizzy spells
  • Panic attacks
  • Skin feeling crawly
  • Migraine headaches
  • Memory lapses
  • Weight gain

Estrogen has 400 functions in the body including:

  • Stimulates the production of choline acetyltransferase, an enzyme which prevents Alzheimer’s disease
  • Increases metabolic rate
  • Improves insulin sensitivity
  • Regulates body temperature
  • Helps prevent muscle damage
  • Helps maintain muscle
  • Improves sleep
  • Reduces risk of cataracts
  • Helps maintain the elasticity of arteries
  • Dilates small arteries
  • Increases blood flow
  • Inhibits platelet stickiness
  • Decreases the accumulation of plaque on arteries
  • Enhances magnesium uptake and utilization
  • Maintains the amount of collagen in the skin
  • Decreases blood pressure
  • Decreases LDL and prevents its oxidation
  • Helps maintain memory
  • Increases reasoning and new ideas
  • Helps with fine motor skills
  • Increases the water content of skin and is responsible for its thickness and softness
  • Enhances the production of nerve-growth factor
  • Positive effect on emotions
  • Increases HDL by 10 to 15%
  • Reduces the overall risk of heart disease by 40 to 50%
  • Decreases lipoprotein(a)
  • Acts as a natural calcium channel blocker to keep arteries open
  • Enhances energy
  • Improves mood
  • Increases concentration
  • Maintains bone density
  • Helps prevent glaucoma
  • Increases sexual interest
  • Reduces homocysteine
  • Decreases wrinkles
  • Protects against macular degeneration
  • Decreases risk of colon cancer
  • Helps prevent tooth loss
  • Aids in the formation of neurotransmitters in the brain such as serotonin which decreases depression, irritability, anxiety, and pain sensitivity

Graham, B., et al., “Sex hormones are associated with rumination and interact with emotion regulation strategy choice to predict negative affect in women following a sad mood induction,” Front Psychol 2018; 9:937.

Natural Estrogen

  • E1 called Estrone
  • E2 called Estradiol
  • E3 called Estriol

Estrone (E1)

  • The main estrogen the body makes postmenopausally
  • High levels many researchers believe may increase a women’s risk of breast cancer

Estradiol (E2)

  • Increases HDL
  • Decreases LDL and total cholesterol
  • Decreases triglycerides
  • Helps maintain bone structure
  • Increases serotonin
  • Decreases fatigue
  • Works as an antioxidant
  • Helps maintain memory
  • Helps absorption of calcium, magnesium, zinc

Results of a new trial reveal that estradiol has a direct effect in reducing atherosclerosis by reducing cholesterol accumulation in the arterial wall.

Reference: Karim R, et al. Abstract MP09. Presented at: American Heart Association Epidemiology, Prevention, Lifestyle and Cardiometabolic Health Scientific Sessions; March 3-6, 2020; Phoenix.

Estriol (E3)

  • Is 80 times weaker than E2 so has a lesser stimulatory effect
  • Considerable evidence exists to show that it protects against breast cancer
  • Experimentally E3 is being used in breast cancer patients
  • It does not have the bone, heart, or brain protection of estradiol.

Functions of E3 in the Body

  • Helps maintain pregnancy
  • Benefits the vaginal lining
  • Blocks E1 by occupying the estrogen receptor sites on the cells of the breasts
  • Controls symptoms of menopause
  • Deceases LDL
  • Increases HDL
  • Helps reduce pathogenic bacteria
  • Helps restore the proper pH of the vagina, which prevents urinary tract infections
  • Helps the GI tract maintain a favorable environment for the growth of lactobacilli

Estrogen and the Brain

  • Common comments I hear from patients are the following:
  • “I think that I am losing my mind.”
  • “I feel like my body is divorcing itself.”
  • “I have lost the ability to spell.”
  • “I am always losing my keys.”
  • “I may be getting Alzheimer’s disease.”
  • Increases blood flow
  • Increases glucose and oxygen to the neurons
  • Protects neurons
  • Increases neurotransmitters
  • Keeps the blood-brain barrier working
  • Increases sensitivity to nerve growth factor
  • Decreases neuronal generation of Alzheimer’s beta amyloid peptides
  • Is a natural antioxidant
  • Increases manual speed and dexterity
  • Increases availability of acetylcholine
  • Boosts by 30% NMDA receptors to maintain strength and durability of synapse connections involved in creating long-term memories
  • Decreases distractibility
  • Turns on progesterone receptors

Estrogen Deficiency

  • Estrogen deficiency has been suggested to be a state of accelerated aging.

Reference: Birge, S., “The use of estrogen in older women,” Clin Geriatr Med 2003; 19(3):617-27.

Estrogen Replacement

  • The method of estrogen delivery is vital in assessing its benefits and uses.
  • Always prescribe estrogen transdermally or transvaginally.
  • For example, the use of estrogen transdermally, in stark contrast to orally, has been linked to a lower risk of deep vein thrombosis, cholecystitis, osteoporosis, and stroke.

Ref: Valdes, A., et al., “Estrogen therapy,” Stat Pearls (Internet) May 30, 2020.

Estrogen Given by Mouth

  • Increases blood pressure
  • Increases triglycerides
  • Increases estrone
  • Causes gallstones
  • Elevates liver enzymes
  • Increases SHBG (decreases testosterone)
  • Interrupts tryptophan metabolism and consequently serotonin metabolism
  • Lowers growth hormone
  • Increases prothrombic effects
  • Increases CRP
  • Increases carbohydrate cravings

Click here to read our blog! Estrogen Dominance - Help is Here!

Suggested Testing:
Saliva/Blood Spot Combo Kit Test
Saliva 5 Test