Susan Merenstein, Pharmacist/Owner

(412) 586-4678


The hormone of love and cuddle

I have good news—you weren't sure if the oxytocin would stay effective for more than 2 weeks, and I'm happy to report that after nearly a month, it's still working... and still at maximum fireworks strength I'm pretty sure! My guy has been enjoying it too since it apparently rubs off on your guy (sorry couldn't resist the pun). It absolutely helps you have a faster and more intense but completely natural-feeling orgasm. It's great to feel something start working not with the feeling of a drug or aid, but feeling like it's all you at your most responsive. Another nice effect that I don't think you had mentioned was that it gives me more feeling in areas that are usually kind of neutral for me, like the lower labia. Really nice stuff! If I can stand to hang onto a couple of doses for awhile, I'll give you a follow-up on how long it stays effective... I think it would be a great selling point for you to have a couple of reviews that mentioned that it will be fine beyond the two weeks.

Oxytocin for Orgasm

Oxytocin and Sex
Also known as the "cuddle" hormone, oxytocin is released by both men and women at sexual orgasm.

Oxytocin hormone questions

Q. I would love to find out if men can boost their mood by having regular orgasms or sex. Are there any feel-good, mood-boosting chemicals released during sex that might help naturally boost a guy's mood? If so, how do they work in the body? How long do they last to help boost a guy's mood or help him relax, etc.? What else should men know about sex and their mood?

A. Men can temporarily improve their mood through sex and orgasms which can last several minutes, hours, or days depending on the depth of connection and intimacy with the partner. Oxytocin is one major hormone that is released through orgasm and its effects normally last minutes or hours. If there is a connection and love with the partner, the afterglow of the sexual connection and mood lift can last a long time. However, in most men, sex is not a reliable and consistent way to improve mood. If there is no emotional connection with the partner, there can actually be a let down after the sexual act. Oxytocin is secreted from the pituitary gland. Oxytocin receptors are found in many parts of the brain and spinal cord, including the amygdala and brainstem.

Q. I was advised by my urologist and my wife by her gynecologist that we should try oxytocin to address our inability to reach orgasm, but they didn't know where or how to obtain it. Do I need a prescription?

A. At Murray Avenue Apothecary we compound a topical oxytocin gel that may be used for men and women. All formulations of oxytocin do require a prescription from your doctor.

Orgasm and Oxytocin Hormone
Plasma oxytocin levels increase during sexual arousal in both women and men and are significantly higher during orgasm / ejaculation than during baseline testing.

Oxytocin and Massage
Oxytocin can be released by various types of sensory stimulation, for example by touch and warmth. Bloodstream levels of oxytocin have been shown to rise during massage.

Oxytocin and bonding
The levels of oxytocin hormone in a pregnant woman's body play a role in how closely she will bond with her newborn. In animals, oxytocin, dubbed "the hormone of love and bonding," is involved in good parenting and maintaining close relationships. Dr. Ruth Feldman and colleagues at Bar-Ilan University, Ramat-Gan, Israel, studied the role of this hormone in humans and found oxytocin is important in the bonding that occurs between mothers and their infants. Dr. Ruth Feldman and colleagues measured oxytocin levels in 60 pregnant women during the first and third trimester and the first month after delivery. They found that initial levels of oxytocin (first trimester) predicted bonding-related well as maternal bonding to the newborn. Mothers with higher levels of oxytocin at the start of pregnancy showed more bonding behaviors after birth. Psychological Science, November 2007.

Oxytocin Topical Gel - RX ONLY

WARNING: Oxytocin Use During Pregnancy

  • Do not use oxytocin if you are pregnant or suspect that you may be pregnant.
  • Oxytocin may cause induction of labor and result in abortion of pregnancy.
  • It is recommended that women of child bearing age use a reliable method of contraception while using oxytocin and/or consider taking a pregnancy test prior to use.

Murray Avenue Apothecary has been successfully compounding Oxytocin topically in an RX gel to be applied to the clitoris during foreplay to increase orgasm and bonding during sex.


Oxytocin is a nanopeptide hormone that is secreted by the posterior pituitary. Oxytocin produces a wide range effects both peripherally and locally in the brain. It is released in large amounts in females during child birth, nipple stimulation and breast feeding. Oxytocin is released by males and females during sexual arousal and levels are significantly higher during orgasm/ejaculation than at baseline. Oxytocin also plays a role in bonding, desire, social recognition, and trust and is therefore known as the “cuddle” hormone.

Traditionally, oxytocin has been administered as an injection or nasal spray to avoid chemical breakdown by the gastrointestinal tract. It’s most common uses have been stimulation of uterine smooth muscle contraction during labor and milk production during lactation. More recently, oxytocin is being used for its action on receptors located in the amygdala, uterus, testes, heart, and many other tissues to produce the following effects:

  • Stimulation of ejaculation
  • Orgasm- increase intensity, shorten time to orgasm, multiple orgasms, easier to climax
  • Production of vaginal secretions
  • Pleasurable sensation
  • Feeling of well-being, warmth, trust and contentment
  • Relaxation of blood vessels and decrease blood pressure

Oxytocin gel should be applied topically, and may be use by both females and males. Dosing may vary according to indication and patient.

Oxytocin may also help treat male anorgasmia.
Oxytocin is increased during arousal and peaks during orgasm. More recently, a study on humans published in Nature has shown its value in social bonding, increasing trust, and enhancing the sense of well-being. Aim. To test the effectiveness of administering oxytocin in a case of treatment-resistant anorgasmia. Methods. The patient underwent a biopsychosocial evaluation by a psychiatrist trained in sexual medicine and sex therapy for male orgasmic disorder, acquired type. Medical conditions, effect of substances, and psychological issues were ruled out. The patient was properly consented to using oxytocin as an off-label trial. Oxytocin was administered using a nasal spray intracoitally because of its ultra-short half-life. Results. Oxytocin was effective in restoring ejaculation. Conclusions. A case of treatment-resistant male anorgasmia was successfully treated with intracoital administration of intranasal oxytocin.

Cautions and Contraindications:

  • Hypersensitivity to oxytocin or any component of the formulation
  • Invasive cervical cancer
  • Active genital herpes
  • Hypertonic or hyperactive uterus, cephalopelvic disproportion, or other genitourinary conditions
  • May produce antidiuretic effect (water retention)
  • High/excessive doses or hypersensitivity to oxytocin may cause uterine hypertonicity, spasm, tetanic contraction, or rupture of the uterus
  • Do not use if pregnant
  • Patients who are breast-feeding should talk to their doctor before using oxytocin gel. Engogenous levels of oxytocin naturally increase during breast-feeding. Excretion in breast milk is unknown-use with caution.


  • This medication is a gel that should be applied to the skin. Patients should always follow their physician or pharmacist’s instructions. Do not exceed prescribed dose.
  • Wash hands after using.
  • Store in the refrigerator with the cap tightly closed.
  • Keep medication out of reach of children and pets.

Possible Side Effects:
To date, no side effects have been reported with proper use of compounded oxytocin gel. Documented side effects of oxytocin injection include increased blood pressure, heart rate and cardiac output; GI upset; genitourinary spasm, contraction, hematoma, and rupture; afibrinogenemia; hemorrhaging.

Call your doctor or pharmacist if:

  • You experience any side effects.
  • You are taking additional medicines that may interact with this compounded medicine.
  • You have allergies or other medical conditions that should be noted.
  • Information on the label is not clear to you.

Oxytocin: Drug Information. Up-To-Date [online database]. Lexi-Comp, Inc. Accessed 27 August 2010.
Sahalian R. Oxytocin hormone benefits and side effects.
Carmichael MS, Humbert R, Dixen J, et al. Plasma Oxytocin increases in the human sexual response. J Clin Endocrinol Metab, 1987. 64:27-31.
Oxytocin Cellular and Molecular Approaches in Medicine and Research. Ivell R and Russell J, editors. Oxytocin-Induced Penile Erection, Role of Nitric Oxide. Argiolas A and Melis M. Cagliari, Italy: 247; 1995. Plenum Press, New York.
Oxytocin Cellular and Molecular Approaches in Medicine and Research. Increased female sexual response after Oxytocin. Anderson-Hunt M and Dennerstein L. Brit Med J 309:929: 236; 1994 Plenum Press, New York